He has been appointed to numerous government positions by his father's regime, including Minister of Agriculture and Forestry and Second Vice-President, in charge of defense and security, in May 2012.
He was promoted to the position of First Vice-President in June 2016 and Ministry of National Defense and Security in 2018, and leads the country's anti-corruption commission set up in May 2022, known as the CNPCC (Comisión Nacional de Prevención y Lucha Contra la Corrupción).
[7] He lived lavishly at the Beverly Wilshire Hotel[8] and rarely attended class;[7] he dropped out after only five months,[7][8] reportedly at the behest of university administrators.
[11] The New York Times reported in 2004 that Nguema was "a rap music entrepreneur and bon vivant, fond of Lamborghinis and long trips to Hollywood and Rio de Janeiro".
[16] Nguema's foreign interests include two houses in South Africa, worth a combined R50,000,000, a $31,000,000 compound in Malibu, California, US, a 5,000 square feet (460 m2) home on Avenue Foch[11] in the affluent 16th arrondissement of Paris, and the hip hop music record label TNO Entertainment.
[18] On 19 January 2013, Nguema's father, Teodoro Obiang, arrested Roberto Berardi, an Italian building contractor, active for 20 years in Africa.
[23] On 14 September 2018, Nguema flew on an official plane to Brazil with other 9 passengers and had some of their 19 bags searched by the Brazilian border police in Viracopos-Campinas International Airport.
[24] In October 2011, seven years after the United States Senate Homeland Security Permanent Subcommittee on Investigations exposed the Nguema's family secret accounts at Riggs Bank in Washington and five years after non-profit Global Witness discovered his mansion purchase in Malibu; the US Justice Department went to court to seize $70 million (£44m) of his US assets, which include a Gulfstream jet, yachts, cars and Michael Jackson memorabilia.
[25] On 11 June 2012, the United States Department of Justice (DoJ) filed an amended complaint against Nguema, after a judge requested more evidence of the alleged corruption.
"[26] In October 2014, he reached a settlement with the United States Department of Justice to pay the U.S. DoJ some of the funds held at accounts on his behalf, as well as his Malibu home, a Ferrari, and portions of his Michael Jackson collection, for a total estimated value of US$34 million.
[35] In September 2016, the District Attorneys Roger Le Loire and Charlotte Bilger referred Nguema to the Criminal Court of Paris, and issued an arrest warrant through Interpol.
[38] In retaliation, the Foreign Minister of Equatorial Guinea, Simeón Oyono Esono Angue, announced the closure of the country's embassy in London, as the British government sanctioned Nguema.