A former schoolteacher and police officer in Longos, he became the head of the labor federation Katipunan ng mga Anak-Pawis sa Pilipinas in his province of Laguna.

Following the failure of a strike in the La Minerva cigarette factory in Tondo, Asedillo returned to Longos and organized armed peasants against what they saw as socio-economic injustice.

[4] Asedillo joined the Katipunan ng mga Anak-Pawis sa Pilipinas (KAP) in 1929,[5] eventually becoming its provincial chairperson in Laguna.

[1] He joined up with Nicolas Encallado, a veteran of the Philippine Revolution and the Philippine-American War who fled to the mountains over disputes in his local town.

He agreed with Asedillo on multiple issues[6] and was convinced of joining him on hearing that KAP fought for independence against the United States.

[8]: 366 Asedillo roamed around barrios in Laguna and Tayabas and held meetings to explain the objectives of KAP and recruit fighters.

[1] A manhunt for Asedillo and Encallado was launched in November 1935 following the death of three municipal officials and multiple Constabulary forces in Longos.

The area between Laguna and Tayabas where the men were believed to operate in was declared a war zone, and Constabulary forces forcibly concentrated residents in communities and put under intense surveillance.

An informer eventually revealed Asedillo's location in Caldong, Sampaloc to Constabulary troops headed by Lieutenant Jesus Vargas[8]: 366 .

Notes found on their bodies alleged that Asedillo and Encallado had plans to raid towns in Laguna and kill informers and Constabulary officers.

Guerrero III referenced both Asedillo and Encallado in his satirical work, "History" - as sometimes written, which was published in Philippine Magazine in March 1936.