[1] Locsin attended public school from Grades I to IV and later transferred to the Ateneo de Manila where he stayed on until he completed his Associate in Arts degree.
[2] During World War II, when the Free Press was shut down, Locsin fled to Negros Occidental to join the Philippine resistance against Japan.
During this time, he met with friends and lawyers such as future senator José W. Diokno, future Manila mayor Arsenio S. Lacson, and a married member of the Manuel Quezon family Felipe Buencamino III or Phillip Buencamino to form the Free Philippines Newspaper.
Marcos detained Locsin in a military camp, Fort Andres Bonifacio, for several months, along with a fellow journalist, publisher Joaquin Roces, and thousands of other opposition leaders.
He was married to his wife, Rosario, and had three sons, Henry, Ramon and Teodoro Jr., former publisher and editor of the newspaper The Philippines Today.