"[5] Simien and his group have toured internationally, presenting over 8500 live performances in more than 45 countries, and released dozens of solo recordings and collaborations.

[6] He has shared studio and stage with the likes of Paul Simon, Dr. John, The Meters, Marcia Ball, Dave Matthews, Stevie Wonder, Robert Palmer and the roots rockers Los Lobos.

He appears on the soundtrack of the Disney film, The Princess and the Frog set in the French Quarter of New Orleans, featuring authentic Louisiana music scored by Randy Newman.

Since it was created in 2001, Creole for Kidz has reached nearly 500,000 students, parents and teachers in more than 20 states, Mali, Dominican Republic, Brazil, Paraguay, Canada and Australia.

[11][12] Simien and several of his other bandmates, Danny J. Williams, Stan Chambers and Jose Alvarez won their second Grammy in 2013, in the category Best Regional Roots Record for Dockside Sessions, produced by George Receli, (Bob Dylan, White Trash, Lou Garou).