She is best known for her role as high school secretary Lovita Alizay Jenkins-Robinson in The WB sitcom The Steve Harvey Show (1997–2002), for which she received three NAACP Image Award for Outstanding Supporting Actress in a Comedy Series.

Later in 1997, Vaughn was cast as high school secretary Lovita Alizay Jenkins-Robinson for the second season of The WB sitcom The Steve Harvey Show.

She owns a production company alongside her business partner, Cas Sigers, called Nina Holiday Entertainment, that produced films such as Sugar Mommas, A Cross to Bear and Girlfriends' Getaway.

[2] In 2016, Vaughn was cast in the recurring role as housekeeper in Oprah Winfrey Network drama series, Greenleaf opposite Keith David and Lynn Whitfield.

[3] In 2020 Vaughn had a recurring role as Robin in Shona Ferguson's South African TV series, Kings Of Jo'Burg shown on Netflix.