He is found by Dr. Charles Girard, a scientist who has set up a laboratory on the isolated island with his disenchanted wife, Frances, and his assistant Walter Perrera.

The island's natives fear Dr. Girard, as he has been experimenting on a panther, surgically changing it with a series of painful operations into a half-man/half-panther beast, which occasionally escapes from its cage and kills an unwary villager.

Later, the beast escapes again and goes on a rampage, killing Walter and a young servant girl named Selene, and abducting Frances, carrying her off into the jungle.

With William and Charles in hot pursuit, the creature is eventually cornered on the edge of a cliff, where it manages to hurl the mad doctor to his death.

Fleeing towards the beach, the wounded creature is helped by a young native boy, Selene's little brother Tiago, and the unconscious beast drifts out to sea in a small rowboat.

It released by Alpha Video on September 25, 2012. and lastly in a blu ray boxed set of all of Romero's "Blood Island" films by Severin on November 13, 2018.

New York Times critic Howard Thompson gave the film a positive review, complimenting the cinematography and calling it "quiet, sensibly restrained and quite terrifying".

[17] In his book Terror on Tape, James O'Neill wrote, "The first and best Filipino horror film, this grim variation on The Island of Doctor Moreau is better than you'd imagine.