Tessenderlo (Dutch pronunciation: [təˈsɛndərˌloː]; Limburgish: Loei) is a municipality in the Belgian province of Limburg.

It is where the three Belgian provinces of Limburg, Flemish Brabant and Antwerp meet at the front gate of the Averbode Abbey.

The name Tessenderlo means "(the open place in) the forest of the Taxandrians".

It is along the Albert Canal and the European route E313, the highway between Antwerp and Liège, one of the reasons it was the place for the first Belgian "Industrial Zone of National Importance" in the 1960s.

Tessenderlo was the scene of an infamous industrial disaster during World War II, when a stock of 150 tonnes of ammonium nitrate at the chemical plant of Produits Chimiques de Tessenderloo (now Tessenderlo Group) - located near the centre of town - exploded on April 29, 1942, killing 189 people at the plant and in the town.