It originally aired on FX and ran from October 9, 2008, to January 1, 2009.
Besides being an obvious play on testes, including the descended double "e" in its logo, the show's title plays up the vulnerability of test subjects, which is the source of much of the humor in the series.
Two close friends are employed as guinea pigs for a pharmaceutical company.
Each episode deals with the different "Research Products" given to the "Test Subjects".
[citation needed] Paradox Entertainment released the entire series on DVD in Region 1 (Canada only) on February 22, 2011.