Tetrapodophis (Greek meaning "four-footed snake") is an extinct genus of lizard from the Early Cretaceous (Aptian) aged Crato Formation of Brazil.

Tetrapodophis has been considered by some authors to be one of the oldest members of Ophidia; the taxonomic group which includes snakes and some of their closest extinct relatives.

[9] Tetrapodophis possesses small yet well-developed fore- and hindlimbs like a lizard and a long body similar to a snake, around 19.5 cm (7.7 in) in length.

[2] The high number of vertebrae (upwards of 150) in Tetrapodophis and snakes is not seen in other burrowing reptiles with elongate bodies and reduced or absent limbs, meaning that it is most likely not an adaptation for a serpentine form of movement.

[1] The type species, Tetrapodophis amplectus, was named in 2015 on the basis of a complete skeleton (BMMS BK 2-2) preserved on a limestone slab in the Bürgermeister Müller Museum in Solnhofen, Germany, which was labeled as "unknown fossil" until its importance was recognized by paleontologist David Martill[10] when he visited Germany in 2012,[11] and housed in a private collection in a private in a museum in Solnhofen.

[12] While no locality information was provided for the specimen,[12] based on characteristics of the rock it is thought to come from the Early Cretaceous Crato Formation of Northeast Brazil.

al. 2021:[6] Anguimorpha Iguania Serpentes (snakes) Tetrapodophis Adriosaurus Pontosaurus Aigialosaurus Mosasauridae However, a study in 2023 again supported its position as a stem-snake, finding it to be unrelated to mosasaurs.