It currently enrolls more than 7,300 students and offers undergraduate and graduate-level classes, as well as a graduate alternative teacher certification program.

The Texas Legislature authorized $40 million in tuition revenue bonds for this new campus in 2006 under HB 153, contingent on full-time enrollment reaching 1,500 by January 1, 2010.

The campus is being built in part due to a plan by the Texas Higher Education Coordinating Board to enroll 630,000 students in college by 2015.

[20] The university's main campus was constructed on a 580 acres (2 km2) site on the south side of San Antonio, near Loop 410 and Zarzamora.

[25] The architectural firm responsible for the campus plans are Kell Munoz and the Construction Manager at Risk is Bartlett Cocke.

[27] Construction of the permanent main campus began in early 2012 after formal approval of a $75 million university development fund from the Texas A&M System Board of Regents.

[29] The structure features a four-story arch, embossed copper-clad main entry doors, decorative tile mosaic accents, and covered terraces.

[27] The building houses multiple student service offices, classroom and lecture hall space, library and quiet study areas, food court/cafe and campus book store.

The building is named in honor of Senator Frank L. Madla for his legislative and public push efforts in the 1990s and early 2000s to establish a general academic teaching institution on the South Side of San Antonio.

[20] As of 2019[update] all three university dining halls closed after 8:00 pm combined with the estimated thirty minutes round-trip to fast food restaurants.

"[34] Because of a large overflow in housing applicants for the 2021–2022 school year, A&M–San Antonio offered students rooms in three Southside hotels for the fall semester.

[37] Texas A&M University–San Antonio offers 30 majors in diverse areas of study and confers degrees from four colleges and schools.

[39] The university has full accreditation to award baccalaureate and master's degrees from the Southern Association of Colleges and Schools (SACS) and received its ten-year renewal in 2019–2020 academic year.

[40] The university has an 18-to-1 student-faculty ration and offers bachelor's degrees and master's degrees through its four colleges and schools:[39] Texas A&M University–San Antonio's Center for Information Technology and Cyber Security offers students educational programs that will prepare them for careers in information technology and cyber security.

A Bachelor of Applied Arts and Sciences degree is offered to students that have completed technical or vocational credits outside of the university and wish to transfer them towards obtaining this degree with concentrations in Business Information Technology, Information Assurance and Security, Project Management, and Enterprise Resource Planning.

The decision was announced after the Texas A&M System board of regents approved TAMU-SA adding a student fee to support athletics.

[45] The measure was first passed by an overwhelming student body vote to add a $10 per credit hour fee, up to a maximum of $120 per semester, to create and fund the department.

[46] Simultaneously to working with the student government, Texas A&M–San Antonio conducted a feasibility of adding athletics that recommended the university join the RRAC at the NAIA level.

[50] Texas A&M San Antonio also has intramural sports[51] such as, basketball, flag football, sand volleyball, 8 ball pool, and many others.