[1] The TMC has the world's highest density of clinical facilities for patient care, basic biomedical sciences, and translational research.

[2] The Texas Medical Center employs over 106,000 people, hosts 10 million patient encounters annually, and has a gross domestic product of US$25 billion.

[6][7] The TMC is served by the METRORail Red Line, a north-south light rail route which connects the district to Downtown Houston and NRG Park.

In 2011, the center employed over 106,000 people, including 20,000 physicians, scientists, researchers and other advanced degree professionals in the life sciences.

Anderson Foundation matched the state's gift to the university by supplying funds and land on the condition that the hospital be established in Houston and named after its founder.

The hospital, later renamed the Michael E. DeBakey Veterans Affairs Medical Center, opened in 1946 and became a teaching facility for Baylor College of Medicine.

The TMC Library provides access to thousands of current digital books and journals and its John P. McGovern Historical Collections and Research Center houses rare medical books dating back to the 1500s, historical manuscripts such as the McGovern Collection on the History of Medicine, the Menninger Collection of Psychiatry and Psychoanalysis, and the Atomic Bomb Casualty Commission which recorded the aftereffects of the atomic bombings of Hiroshima and Nagasaki.

[12] In 2001, the Texas Medical Center was devastated by Tropical Storm Allison, which flooded basements and the first floors with 18 inches of water.

Texas Children's was undertaking the development of one of the largest pediatric hospitals in a suburban setting ($220 million).

[16][17][18] Texas Medical Center–West Campus, serving residents of greater west Houston and adjacent areas, opened in January, 2011.

[19] In 2012, Texas Medical Center added the Shriners Hospitals for Children in Galveston, which treats pediatric trauma burns, as its 50th member institution.

Denise Castillo-Rhodes, executive vice president and chief financial officer of the Texas Medical Center, as well as a volunteer for San José Clinic noted when it became a member of TMC: "San José Clinic serves a very important role in our community.

Thus, it is a natural next step for the Clinic to join the Texas Medical Center as its newest member, as it continues to grow and provide extraordinary healthcare and education at affordable prices.".

[22] On June 24, 2020, The Texas Medical Center released data showing a 97% capacity in its ICU facilities due to the Covid-19 crisis.

UTHealth School of Dentistry The Texas Medical Center is a dense agglomeration of hospitals, schools, and ancillary businesses clustered on a triangular piece of land bordered by Rice University and the neighborhood of Southampton to the west, Brays Bayou to the south and east, and Hermann Park to the north.

The Texas Medical Center Corporation has compared its dense cityscape to the Chicago Loop and Lower Manhattan.

To compensate, the TMC has developed strong transit connections; the entirety of the district is serviced by the METRORail Red Line, which runs along Fannin.

These three stops are the busiest stations on the Red Line; ultimately, the district's bus, light rail, and shuttle services deliver nearly 65,000 trips per day to and from the area.

[26] In the 2010s, rapid development within the Medical Center began to strain existing transportation infrastructure; the average daily traffic on Fannin Street and nearby arterial Kirby Drive is expected to double by 2035.

[27] New development during the first half of the decade is expected to require an additional 50,000 parking spaces to meet demand.

[27] Solutions to the district's traffic problems include expanding existing arterial roads, boosting transit capacity, and constructing new contract parking lots on the outskirts.

[33] The Texas Medical Center is within the Houston Police Department's South Central Patrol Division.

Members of the orchestra include physicians, dentists, nurses, medical students, biomedical scientists, social workers and other health professionals.

[40] The mission of the orchestra is to provide health care professionals with a high-quality outlet for creative expression through the world of symphonic music; perform regularly at affordable concerts that are open to the public and in an accessible venue; attract a diverse audience by commitments to select popular programming reflecting Houston’s diversity; and bring public attention to, and provide programmatic support for, medically related and/or educational charities.

[41] Organizations which have received contributions include: The University of Texas Medical School for heart research; The Ben Taub BOOKS programs; The H.O.M.E.S Clinic; Making a Mark Art Program at Texas Children’s Hospital; HISD's DeBakey High School for Health Professions; Eye Care for Kids Foundation; The Greater Houston Chapter of the American Red Cross; The National Space Biomedical Research Institute; San Jose Clinic; Haddassah; and The Dr. Marnie Rose Foundation.

[44] By coordinating efforts with KIPP SHARP teachers and administrators, TMCO has integrated its musical programming into the school's curriculum.

The students are invited to display artwork and essays in the Wortham lobby at TMCO concerts, and they are encouraged to attend with their families.

When the COVID-19 pandemic hit in 2020, the Texas Medical Center Orchestra was invited to perform Diane Warren's Oscar-nominated song, "I'm Standing With You" in a monumental music video that featured more than 170 artists from six continents.

Warren teamed up with director Gev Miron and composer/arranger Sharon Farber to put this effort together, which has raised over $7 million for the United Nations Foundation’s COVID-19 Solidarity Response Fund for the World Health Organization (WHO).

[53] In 2014, the Texas Education Agency (TEA) announced that the school's performance was insufficient and that it sought to revoke its charter.