The freeway provides access to the western part of San Antonio, the SeaWorld San Antonio theme park, Chase, Northwest Vista College, and the future site of a Microsoft data center.

The route of SH 151 was originally conceived in 1983 by local land developer Charles Martin Wender and later received approval by Raymond Stotzer, the district supervisor of the Texas Department of Transportation at the time and for whom the freeway would later be named.

[3] During the construction of the freeway, the Texas Turnpike Authority considered SH 151 as a candidate to become a toll road, but this drew much criticism from local politicians and the Bexar County commissioners and did not come to fruition.

[18] The highway provides access to the SeaWorld San Antonio theme park as well as industry along its corridor to include Chase, Hyatt Hill Country Resort, World Savings, Philips semiconductor, the National Security Agency campus, QVC, American Funds, Maxim Integrated Products, and the Northwest Vista College, as well as the nearby Southwest Research Institute.

[18] A new direct, flyover interchange was built connecting eastbound TX-151 with northbound I-410, alleviating traffic at its busiest stretches.

A fully directional, stack interchange has been planned, partially funded, and is set to begin construction in 2019.