In Sugar Land and Missouri City, it is known as Alvin-Sugarland Road and runs perpendicular to Interstate 69/U.S.

That same day, the section in southeast Texas between Hempstead and Sugar Land was canceled, as it was redundant with the new FM 359.

In the early 1970s, the northern section underwent a massive rerouting due to realignments of numerous U.S. and state highways.

In June 2016, a section of the highway in Eastland County between Cisco and Albany was destroyed due to major flooding.

The highway makes a mostly straight line through Galveston, Brazoria, and Fort Bend Counties, passing through the city of Alvin.

As the highway traverses through Sugar Land, it makes a turn to the north after passing intersections with I-69/US 59 and Alternate US 90.

The highway continues north into western Harris County, reaching the Westpark Tollway and I-10.

It then intersects US 290 in CyFair, joining it as they travel to the northwest, thus finishing a large routing around the southern and western portions of Houston.

At Hempstead, it splits from US 290 and turns northward into Grimes County, where it bypasses the city of Navasota, while Business SH 6 passes through town.

The highway starts another bypass here, going around the Bryan–College Station area to the northeast, while the business route goes through these cities.

On the northeast side of Bryan, the highway meets US 190, and they travel together to the northwest out of the region.

SH 6 then continues northwest, traveling through lesser populated farmlands, before approaching Waco.

The highway continues northwest and west through more farmland regions in Central Texas, before reaching an intersection with I-20 just south of Eastland.

Just northwest of Stamford, the highway makes its final turn to the north at an intersection with SH 283.

The route was created in 1972 when SH 6 was rerouted further north and east around town; it is 6.3 miles (10.1 km) long.