Tezozomoc (modern Nahuatl pronunciationⓘ) was the second tlatoani (ruler) of altepetl Ecatepec, in 15th-century Mesoamerica.

[1] Tezozomoc was a son of an Aztec tlatoani Chimalpopoca, ruler of Tenochtitlan.

His mother may have been Matlalatzin.

He was a grandson of tlatoani Huitzilihuitl and Ayauhcihuatl, who was a daughter of the Tepanec tlatoani Tezozomoc, ruler of Azcapotzalco.

He was a relative of and successor tlatoani to Chimalpilli I in 1465.