Thaidene Nene National Park Reserve (from the Dene, this Chipewyan name means land of our ancestors[1]) is a national park in the vicinity of the east arm of Great Slave Lake, located on the northern edge of the boreal forest of Canada in the North Slave Region of the Northwest Territories.

The creation of Thaidene Nene National Park Reserve works to protect caribou and pelt animals such as "lynx, wolf, red fox, wolverine, marten, moose and black bear".

[1] Other mammals inhabiting this park reserve include Arctic fox, beaver, muskox, grizzly bear and barren-ground caribou.

[5] The area features red granite cliffs, as well as "a spectacular array of peninsulas, canyons and waterfalls as the forests give way to northern tundra".

The federal government's 2016 budget named the Thaidene Nene proposal in its allocation of funds to help the National Park Reserve to realization.