It follows a coastal route from Bangkok to Khlong Yai District, Trat border to Koh Kong, Cambodia.

Starting from where the boundaries of the districts of Khlong Toei, Pathum Wan and Watthana meet, it runs the entire length of the border between Khlong Toei and Watthana, then passes through Phra Khanong and Bang Na districts.

The Sukhumvit area of Bangkok is easily accessible on the Sukhumvit line of the BTS Skytrain, which runs from Khu Khot in Lam Luk Ka, Pathum Thani through the Silom Line interchange at Siam up to Kheha in the centre of Samut Prakan province.

Restaurants of various levels of luxury exist all along the road, as well as hotels including famous names such as The Westin, JW Marriott, Sheraton, Ramada Hotel and Suites Bangkok Sukhumvit, and Four Points by Sheraton.

It also harbours the eastern bus station at Soi 63, also known as Ekkamai Road.