Active since the early 1980s, she has been a member of several notable alternative rock groups, including Live Skull and Uzi both of which, according to Spin magazine, "made big noise in the underground",[1] and Come.

Critic Heather Phares writes that Zedek's music can be defined by "the permanent, aching rasp in her voice, her guitar's bluesy bite, the startlingly clear-eyed lyrics about life and loss.

[4] This group had somewhat more success, including a single, "Smile on Your Face/Alpha Romeo", which achieved airplay on college and alternative-commercial radio; but Zedek wanted a more "violent" sound in contrast to the somewhat "girlie pop" tendencies of her Dangerous Birds bandmates.

The EP was characterized by elusive yet subtly menacing lyrics superimposed upon lugubrious but driving instrumental tracks, featuring layers of dense, murky yet muscular guitar arrangements, blended with heady synthesizer and tape effects.

In spite of limited commercial success, Zedek has been acclaimed by music critics throughout her career, and has arguably been deeply influential within the indie-rock realm, particularly through her influence within the prolific Boston indie scene, which has spawned many noteworthy artists.