The southern end of Thane–Belapur Road starts at the Sion Panvel Highway near Juinagar.

The road passes through a busy Thane – Belapur region and generally runs in a north–south direction.

During the stretch between Turbhe and Digha, the Thane–Belapur Road runs completely parallel to the Trans-Harbour Line of Mumbai Suburban Railway and the stations of Airoli, Rabale, Ghansoli, Kopar Khairane and Turbhe all have direct access from this road.

This road also connects the cities of Thane, Kalwa, and Airoli to the Mumbai-Pune Expressway.

Several major industrial parks such as MIDC, Airoli IT Park, Reliance Jio Infocomm Limited, Dhirubhai Ambani Knowledge City, Millennium Business Park, Reliance Hospital,[1] and DY Patil Stadium are located beside this road in addition to many other businesses and corporate premises.