The game is set in the United Kingdom, and the player is tasked with killing former prime minister Margaret Thatcher, who has risen from the dead.

Thatcher's Techbase is a WAD for Doom 2, and largely retains the same first-person shooter gameplay, but features new weapons, levels, and enemies.

[4] In Thatcher's Techbase, Margaret Thatcher, "one of humanity's greatest threats",[5] rises from the dead, leading the player to descend into the tenth circle of Hell, the United Kingdom, in order to kill her and send her back to Hell.

[6] The game's soundtrack is composed by Barry "Epoch" Topping, who also wrote the music for Paradise Killer.

[8] In September 2022, Thatcher's Techbase featured in a number of British newspapers when former Labour leader and independent MP Jeremy Corbyn was pictured playing an arcade version of the game at The World Transformed in Liverpool.