[1][5] The 78 will also include a $1.2 billion research center called the Discovery Partners Institute, which will be operated by the University of Illinois.

In April 2019, the Chicago City Council approved The 78 development, including a tax increment financing agreement.

These include Lincoln Yards, 400 Lake Shore Drive, Tribune East Tower, One Chicago, Southbank, Riverline, Bronzeville Lakefront, an $8.5 billion revamp of O'Hare International Airport, a city casino, an extension of the Red Line subway/elevated train, and the Barack Obama Presidential Center among other large scale projects.

[11] In 2024, it was reported that the Chicago White Sox and its owner Jerry Reinsdorf were in discussions with Related Midwest to potentially build a new stadium on the site to replace Rate Field following the end of the team's lease in 2029.

[13][14][15][16] Between August and September 2024, the White Sox and developer Related Midwest built a temporary field on the site.