[1] Film stars Bud Abbott and Lou Costello adapted their talents to radio for the 30-minute weekly comedy program.

Vincent Terrace, in his book, Radio Programs, 1924-1984: A Catalog of More Than 1800 Shows, wrote, "Many of the skits revolved around Bud and Lou's efforts to succeed in some sort of business venture.

[4] Supporting players included Elvia Allman (usually as Mrs. Niles, fictional wife of announcer Ken Niles), Joe Kirk (Costello's brother-in-law, most often as a heckler), Artie Auerbach as Mr. Kitzel, Iris Adrian (as Costello's sometimes girlfriend Lena Genster), Mel Blanc (many characters, including guest spots as Bugs Bunny), Sidney Fields (as Melonhead), Wally Brown, John Brown, Sharon Douglas, Verna Felton, Frank Nelson, Kent Rogers, Martha Wentworth and Benay Venuta.

Orchestra leaders were Skinnay Ennis, Charles Hoff, Matty Matlock, Jack Meakin, Will Osborne, Freddie Rich, Leith Stevens and Peter van Steeden.

[6] A related program, The Abbott and Costello Children's Show, was broadcast on ABC beginning December 6, 1947 and ending March 26, 1949.