The Actors' Gang has presented the work of theater artists including Georges Bigot, Simon Abkarian, Charles L. Mee, David Schweizer, Bill Rauch and the Cornerstone Theatre Company, Tracy Young, Roger Guenveur Smith, Eric Bogosian, Oskar Eustis, Danny Hoch, Beth Milles, Jon Kellam, Brian Kulick, Stefan Haves, Namaste Theater Company, Culture Clash, JR Reed, Michael Schlitt, and Tenacious D. The Actors' Gang ensemble has included actors such as Jack Black, John Cusack, John C. Reilly, Helen Hunt, Kate Walsh, Fisher Stevens, Jeremy Piven, Ebbe Roe Smith, Jon Favreau, Lauren Lane, Brent Hinkley, Kate Mulligan, Lee Arenberg, Kyle Gass, and Tim Robbins.

[citation needed] Guest artists that have appeared on The Actors' Gang stage include: Jackson Browne, Sarah Silverman, Ben Gibbard, John Doe, Tom Morello, Jenny Lewis, Wayne Kramer, Paul Provenza, Zooey Deschanel, Serj Tankian, David Crosby, Felicity Huffman, Jill Sobule, William H. Macy, Phillip Baker Hall, Jeanne Tripplehorn, T. C. Boyle, and Gore Vidal.

[citation needed] In 2014, the Actors' Gang toured its production of William Shakespeare's A Midsummer Night's Dream, directed by Tim Robbins.

These productions have toured 41 states in the U.S. and cities across the world from London to Athens, Madrid, Barcelona, Bogota, Hong Kong, Melbourne, and Buenos Aires, covering five continents.

It includes elements of commedia del arte, mask work, viewpoints, and focuses on developing emotional states.