Each episode is following a different couple: In the first story, Roberto is a lawyer sent to a rural town in Tuscany to convince a family of old farmers to sell their land.
When one of them ends with a damage to a police car, Fabio learns that Elaine is suffering from bipolar disorder and has a history of mental breakdowns.
He tries to end the affair, but she begins to stalk him, threatening him with a home video recording of them having sex and finally tearing down his apartment.
His wife and daughter leave after he discloses his infidelity, and Fabio has a breakdown on live air, which has him demoted to a field reporter in Africa.
After he fights an abusive former boyfriend, Viola takes interest in Adrian and learns that he had serious health problems, having gone through a heart transplant operation which left him physically and emotionally scarred.
Adrian suffered from depression after his operation, which ended his marriage, and Viola tried to open a restaurant with a loan from local gangsters, but didn't succeed.
The final scene of De Niro and Monica Bellucci was filmed in the Villa Pizzetti Hospital in Grosseto, on 20 October.