The Alisher Navoi State Museum of Literature of the Academy of Sciences of Uzbekistan is a scientific-cultural, educational establishment which mainly focuses on collecting and researching the historical materials and objects which are related to Uzbekistan's history.

The museum plays a role in the cultural development of young generations in Uzbekistan and it keeps various documents, manuscripts from the Middle Ages.

The Alisher Navoi State Museum of Literature was first established as the exhibition for the 500 year anniversary of Ali-Shir Nava'i.

However, on 18 January 1967 the museum was set to be independent by the edict of the Uzbek government and was given a new 4 level building in Tashkent city.

On 13 September 1989 the museum was made independent for the second time by the Central committee of Uzbekistan and by the Department of Ministers of Uzbek Soviet Socialist Republic (UzSSR).