Hosted by Phil Keoghan, it featured twelve teams of two, each with a pre-existing relationship, competing in a race around the Euro-Mediterranean region to win US$1,000,000.

Starting in Munich, racers traveled through Germany, Austria, Italy, Jordan, France, Spain, and Iceland before returning to the United States and finishing in Nashville.

Production began on May 22, 2022, with the teams and filming crew departing from Los Angeles International Airport on a chartered Titan Airways Boeing 757, so as to reduce prolonged personal interactions associated with COVID-19 infections much like in the previous season.

[14] On October 5, the season began airing in the Wednesday 10:00 pm time slot, following Survivor and The Real Love Boat.

Starting on November 2, The Amazing Race was moved forward to the 9:00 pm time slot when The Real Love Boat was shifted onto Paramount+.

[15] Prior to the premiere, CBS News Sunday Morning aired a segment with correspondent Tracy Smith competing on the first leg with her husband.

[17] The cast included Big Brother 23 HouseGuests Derek Xiao and Claire Rehfuss,[18] former Los Angeles Rams cheerleader Quinton Peron, and former New York Jets and Buffalo Bills head coach Rex Ryan.

[20] Aubrey Ares and David Hernandez were not initially selected for the final cast, but were called to compete two hours before The Amazing Race started production.