The game was developed by Oxford Digital Enterprises and released in 1990 for Commodore 64 and Amiga,[3] and later ported to IBM PC compatibles, Amstrad CPC, and Atari ST.

[2][3] The plot involves Spider-Man's wife, Mary Jane, being kidnapped by Mysterio.

To save her, Spider-Man must navigate through various environments and puzzles divided into separate acts, representing Mysterio's obsession with film.

[1] In December 1990 issue of British gaming magazine The One, Rick Yapp from Oxford Digital Enterprises was interviewed about The Amazing Spider-Man's development.

Because he can be shown in all orientations, such as walking along ceilings and crawling up walls, there's 256 frames of animation just for the Spider-Man sprite".