The programme shared a studio with Sunday Politics, Newsnight and HARDtalk, BBC World News, GMT, Impact, Global and Focus on Africa.

The Andrew Marr Show usually featured one Cabinet-level UK minister, a representative from the Opposition, one big-name, non-political guest and two or three celebrities or journalists to review the Sunday papers.

interviewees included: Dmitry Medvedev (then President of Russia), Morgan Tsvangirai (then Prime Minister of Zimbabwe), Tony Hayward (then CEO of BP), Anthony Hopkins, Nicole Kidman, Russell Crowe, Ban Ki-moon (UN Secretary-General), Michael Caine, Kevin Rudd (then Prime Minister of Australia), David Cameron, Theresa May and Boris Johnson.

[3] Musical guests included: Tom Jones, Sting, Jay-Z, Snow Patrol, George Ezra, James Bay, Rag 'n' Bone Man, Sir Ray Davies, Marc Almond, Jools Holland, Florence and the Machine, Lulu, Boy George, and Sir Elton John.

Guest presenters included: Zeinab Badawi, Sophie Raworth, Fiona Bruce, Stephanie Flanders, Huw Edwards, Martha Kearney, Emily Maitlis, James Landale and Jeremy Vine.

Marr appeared as a guest on the show on 14 April to speak about Margaret Thatcher's legacy, and spoke about the incident and his recovery.

Paralysis of the left side of his body was evident, but his speech was unaffected, and he expressed determination to return to the presenter's role.

The guest presenters who appeared included Jeremy Vine, Sophie Raworth, James Landale, Eddie Mair, Sian Williams, Susanna Reid and Nick Robinson.

The issue of his health and whether it affects his ability to perform the onerous job of leading the party and the country was pertinent, and has been raised with other Prime Ministers in the past.

"[12]Marr himself, appearing at the Leveson Inquiry in May 2012, defending the question as "reasonable", but also regretted asking it, because it dominated newspaper headlines rather than the more serious policy points covered in the interview.

[9] During Marr's absence from the programme, on 24 March 2013, guest presenter Eddie Mair interviewed the Mayor of London Boris Johnson, asking critical questions about Johnson's known past misdeeds – the subject of a forthcoming BBC documentary by Michael Cockerell – including lying to Michael Howard, his party leader, and offering to supply the name of a journalist to a friend who wanted to beat him up, Mair concluded his line of questioning with: "aren't you in fact – making up quotes, lying to your party leader, wanting to be part of someone being physically assaulted – you're a nasty piece of work, aren't you?

"[13] Patrick Wintour, political editor of The Guardian commented that Johnson's "reputation" took "a severe pounding",[14] while The Daily Telegraph blogger Dan Hodges said Mair's approach was a "disgrace".

[22] In August 2019 it was announced that The Andrew Marr Show was moving back to 9 am, again in direct competition with Ridge after a year-long "experiment".