Longtime friend and collaborator Pat Hackett maintained the diary for eleven years and reflects on the life of the artist.

The series traces Warhol's relationships with interior designer Jed Johnson, Paramount Pictures executive Jon Gould, and fellow artist Jean-Michel Basquiat.

[10][11] Others interviewed for the series include Bob Colacello, Christopher Makos, Rob Lowe, Jerry Hall, Mariel Hemingway, Tony Shafrazi, Mary Boone, Vincent Fremont, Shelly Dunn Fremont, Jamie Wyeth, Glenn Ligon, Larry Gagosian, José Carlos Diaz, David LaChapelle, Wilfredo Rosado, Peter Wise, Donna De Salvo, Jay Johnson, Kenny Scharf, Alan Wanzenberg, Michael Chow, Patrick Moore, John Waters, Greg Tate, Julian Schnabel, Marc Balet, Lee Quiñones, Donald Warhola, Futura 2000, Daniela Morera, Debbie Harry, Paige Powell, John Reinhold, Gigi Williams, Jay Gould, Jeffrey Deitch, Jessica Beck, Cornelia Guest, Madelyn Kaye, Lisa Birnbach, Fab 5 Freddy, R. Couri Hay, Benjamin Liu, Lucy Sante, Tama Janowitz, Katy Dobbs, Whit Stillman, and Jane Holzer.

The website's critics consensus reads, "Employing some risky stylistic flourishes that Andy Warhol himself might have approved of, these Diaries are a revelatory glimpse into the inner life of a purposefully unknowable artist.

[16] Daniel D'Addario of Variety wrote that "the series both summons Warhol's affectless voice and insists on finding the intellect and emotion behind the coolly evaluating gaze".