López gained notoriety in Colombia after releasing his show called La Pelota de Letras (The Ball of Letters) which earned him a Double Diamond award from Universal Music.

Later the University assigned a classroom for him to teach the art of stand-up comedy to people interested in performing dramatic and comedic theater.

He also created the University Newspaper “El Mercurio” where there was room for people to express themselves artistically by placing their stories, paintings, poems and photographs.

There he became a creative force by developing many comedy skits such as 'Tratame Suavemente' (Treat me Softly) better known as 'Catalina y mi Andy', 'Juan Bracitos' (Juan Little Arms), 'Jason Libardo' and many others for the morning show also known as El Mañanero.

López's most recognized show The Ball of Letters-La Pelota de Letras consists of a subtle sociological analysis of life in Colombian families between the 1960s and the 2000s (decade).

In December 2005, he launched, La Pelota de Letras on DVD in the Hard Rock Cafe Bogota under the Universal Music Colombia label .

[15] On January 19, 2008, for the first time a Colombian, Andrés López, performed on South Beach Comedy Festival sponsored by IMPROV, Comedy Central, The Miami Herald and others, at The Fillmore, The Jackie Gleason Theatre 7:30pm, January 16–19, 2008 [14] Andrés performed with other comedians like Kathy Griffin, nominated to the Emmy Awards and famous for been the cast on the show Suddenly Susan, Brooke Shields.

Other Comedians: Dave Attell, Jeff Dunham, Jeffrey Ross, Katt Williams, Kristina Wong, Louis C.K., Ralphie May and Stephen Lynch.

[14] 25, November 2008, The Second Commission of the Senate of the Republic of Colombia presented Andres Lopez with the Order of Merit to the Democracy in the Degree of Great Gentlemen.

[14] Andrés performed to golfers at the Club Country de Bogota as a welcome to the Nationwide Tour after the Celebrity Pro-Am of Juan Pablo Montoya to the benefit of Formula Sonrisas and Camilo Villegas Fund.

[27] "Frutica Picada" was aired exclusivity on OnDIRECTV, from 11 to 14 of June to the countries: Argentina, Peru, Chile, Venezuela, Ecuador, Puerto Rico, Uruguay and the Caribbean.

DirecTV officially published a document on its website that indicates that the show had the highest rating in Latinoamérica in June and July second only to the Opening of the World Cup FIFA 2010.

[28] September and October 2010 Andrés López was the host and performed his Stand-Up Comedy at the International Humor festival for Caracol Television,[29] Colombian Televisión Network.

[30] In January 2011 DirecTV Latin America bought the rights from Caracol Televisión[29] to air the International Humor Festival where Andrés was the host.

The festival is currently airing on DirecTV throughout Argentina, the Caribbean, Chile, Colombia, Ecuador, Peru, Puerto Rico, Uruguay and Venezuela.

[43] The most important newspaper in Colombia, El Tiempo, has also described his show The Ball of Letters-La Pelota de Letras as: "The performance portrays the customs of recent generations of Colombians, which is better than any sociology study".

Companies using López include: Hewlett-Packard, Alquería, Oracle Corporation, Roche, Microsoft, Merck & Co., IBM, The Coca-Cola Company, BAT, Unilever, Grupo Santander, Porvenir, ETB, Intel Corporation, Nestlé Purina PetCare, Nestlé, Avantel, Alpina, Bavaria, Altria Group, Colsubsidio and more.