The tournament, involving 64 teams, began on July 16 and ended on August 2 with the championship game in Dayton, Ohio.

For the first time, the event had a "championship week", starting with the regional winners advancing to quarterfinals at one of two sites, Dayton and Wichita, Kansas.

Blue Collar U, a team primarily rostered with alumni of the Buffalo Bulls men's basketball program, won the tournament.

[3] The eighth regional site was revealed on May 19, 2022, as Rucker Park, an iconic outdoor venue in the New York City neighborhood of Harlem.

[4] In a feature it calls "Run It Back", TBT organizers invited all teams that won first-round games in the 2021 edition to play in 2022.

[5] The remaining teams, and the regional placements for all entrants, were revealed in a selection special hosted by Chris Vosters with analysts Seth Greenberg and April Gray that aired on TBT's YouTube channel on June 22, 2022.

Five other teams were rostered primarily with alumni from groups of NCAA basketball programs sharing a common bond.

Announcers for both semifinal matches and the championship game were Bob Rathbun, Fran Fraschilla, and Angel Gray.

[16] The final points of the tournament, securing the championship for Blue Collar U, came on a dunk by Montell McRae.