A group of ragtag detectives from the Pizzofalcone police station in Naples investigate complex cases.

The series is filmed in various locations around Naples, including the Palazzo Carafa di Santa Severina, the Certosa di San Martino, the Toledo station, the Quartieri Spagnoli, Mergellina, the Universitá Monte Sant'Angelo, Santa Caterina a Formiello, Sant'Anna dei Lombardi, Largo Tarsia, the Piazza del Gesù Nuovo, Largo Sellaria, Villa Gallotti, and the Centro Direzionale.

[4][5] The third season began production in late 2018[6] and premiered on 20 September 2021.

[8] The lesbian relationship between Alex Di Nardo and Rosaria Martone[11] resulted in complaints from the Catholic newspaper Avvenire as well as from Maurizio Lupi, a member of the Italian Parliament and Popular Area coalition.

[12][13] In response, star Alessandro Gassmann tweeted, "I want to thank Avvenire for the controversy over the lesbian scenes in Pizzofalcone!