The children of Mitchell Brook Primary School in Neasden acted out news stories that happened throughout the year, such as Ricky Gervais winning two Golden Globe Awards for The Office and the Momart fire.

This was until towards the end when Jimmy Carr bowed to the pressure of the studio audience and gave them 22 points for answering one question correctly, which was the amount needed to bring them back into contention at the time and ensuring that they subsequently won the quiz.

Due to the furore caused by his and Russell Brand's infamous phone call to actor Andrew Sachs, which resulted in his three-month suspension from the BBC at the end of the year, this was the first occasion that Jonathan Ross did not appear.

In-studio guest questions came from Strictly Come Dancing contestants Jodie Kidd and Mark Foster, and 2008 Olympics Team GB gold medalists Christine Ohuruogu and James DeGale.

Newsreader Jon Snow again appeared with news reports on "Poker Face" and "Bonkers" and the children of Mitchell Brook Primary School also reprised their regular slot, acting out the Parliament expenses scandal and Kanye West invading the stage at the MTV Video Music Awards.

[5] Guest questions were provided by Cee Lo Green, Michael Sheen, Tulisa, Lee Evans, Muppet drummer Animal, Rastamouse, Downton Abbey star Jim Carter, Lenny Kravitz, and Professor Brian Cox.

The children of Mitchell Brook Primary School acted out the arrival of Larry the Cat at 10 Downing Street and Cheryl Cole's firing from The X Factor, and Jon Snow gave his news reports on Rebecca Black's "Friday" and Jessie J's "Price Tag".

Recorded guest questions were provided by PSY, Gerard Butler, Usain Bolt, Jessica Ennis, Felix Baumgartner, Kylie Minogue, Cheryl Cole, Simon Callow, Jenson Button, Tom Daley, Warwick Davis, and Charles Dance (doing a dramatic reading from Fifty Shades of Grey).

Pre-recorded guest questions were provided by Russell Brand, Anchorman 2 stars Steve Carell, Will Ferrell, and Paul Rudd; Olly Murs, Christine Ohuruogu, Louis Walsh, Richard Osman, The Great Gonzo (promoting Muppets Most Wanted), Harry Hill, and Sophie Ellis-Bextor, Educating Yorkshire teachers Mr. Mitchell and Mr. Burton, The Great British Bake Off series 4 runner-up Ruby Tandoh, Rizzle Kicks, and astronaut Chris Hadfield.

[9] Pre-recorded guest questions came from Michael Palin, Tom Daley, the cast of The Inbetweeners, Game of Thrones actress Natalie Dormer, Lily Allen, Rio Ferdinand, Pixie Lott and Status Quo members Francis Rossi and Rick Parfitt.

[13] Pre-recorded guest questions came from Quentin Tarantino, Rita Ora, Simon Pegg, Will Ferrell and Mark Wahlberg, Josh Groban, Olly Murs, Katie Price and Heston Blumenthal.

Pre-recorded guest questions came from Professor Green, Bryan Cranston and James Franco, The Vamps, Sadiq Khan, Ryan Tedder and Zach Filkins from OneRepublic, Miranda Hart, Gemma Chan, Michelle Keegan and Rick Astley.

Pre-recorded guest questions came from Simon Callow, George Ezra, Alex Jones, Jonas Blue, Joe Sugg, Sheridan Smith, Emma Willis and Georgia Toffolo.

Pre-recorded questions came from Joe Wicks, Bob Odenkirk, Carole Baskin, Laura Whitmore, Craig David, Keith Lemon, KSI, Chris Kamara, Nicola Coughlan, and LadBaby.

The mystery guest was Billy McLean, whose joke WhatsApp voice memo started a false rumour that the British government was planning to combat hunger during lockdown by making a lasagne the size of Wembley Stadium.

Pre-recorded questions came from Dr. Catherine Green (one of the University of Oxford team responsible for developing the Oxford–AstraZeneca COVID-19 vaccine), Robert Peston, Clara Amfo, Ellie Simmonds, Andi Oliver, Briony May Williams, and Downton Abbey: A New Era's Elizabeth McGovern and Laura Carmichael.

The mystery guest was Jerry Dyer, the creator and narrator of the YouTube channel Big Jet TV, whose livestream of planes attempting to land at Heathrow Airport during Storm Eunice went viral.

Pre-recorded guest questions came from Self Esteem, Anyone but You stars Sydney Sweeney & Glen Powell, Robbie Williams, The Vivienne, Big Brother presenters AJ Odudu & Will Best, Micah Richards and Sophia Di Martino.

[17] Pre-recorded guest questions came from Chiwetel Ejiofor & Leo Woodall, Aidan Turner & Danny Dyer, David Jonsson, Richard Curtis, Nella Rose, Dame Sarah Storey and Love is Blind contestants Jasmine and Bobby.

Pre recorded questions come from Anna Friel, Jonathan Ross, Quentin Tarantino, Ricky Gervais, Jools Holland, Ram John Holder, Derren Brown, and Jo Frost.

[9] Pre-recorded guest questions came from Ian McKellen, Paul Hollywood and Mary Berry, Chico, Gregg Wallace, Ellie Simmonds, Peter Andre and Abbey Clancy.

Pre-recorded guest questions came from Little Mix, Gareth Malone, Paul Whitehouse, Joey Essex, Jessica Ennis-Hill, Dom and Steph Parker from Gogglebox, Kevin McCloud, Darcey Bussell and Alesha Dixon.

[22] Pre-recorded guest questions came from Joe Wicks, Nick Hewer, Joey Essex, Laura and Jason Kenny, Derren Brown, Ollie Locke from Made in Chelsea and Darcey Bussell.

Pre-recorded guest questions came from Brendan O'Carroll, Stacey Solomon, Eric Idle, Asim Chaudhry (in character as Chabuddy G from People Just Do Nothing), Basil Brush, Clara Amfo and Boyzone.

The Big Fat Question involved lookalikes of Elton John, Diana Ross, Ed Sheeran, Stormzy and Lady Gaga, with the teams having to place them in order of most weeks spent at number one in the UK Singles Chart.

Recorded guest questions were provided by Su Pollard, Michael Fish, Clare Grogan, Roland Rat, Nik Kershaw, The Proclaimers, Anne Charleston, Charles Dance (doing a dramatic reading from the autobiography of The Krankies), and Sonia.

Recorded guest questions were provided by Gregg Wallace, Nick Bateman, Peter Andre, half of McFly, Gareth Gates, Tara Palmer-Tomkinson, and Charles Dance (doing a dramatic reading from the autobiography of Katie Price).

Recorded guest questions were provided by Mr. Motivator, Goldie, Andi Peters, Tony Mortimer, Melinda Messenger, Daniela Nardini, Sally Gunnell, The Shamen's Mr. C, the members of Hanson and Charles Dance (doing a dramatic reading from the autobiography of Vanilla Ice).

The children of Mitchell Brook Primary School made an appearance acting out the infamous "hair-dryer treatment" done by Manchester United manager Alex Ferguson to David Beckham after losing to Arsenal at the 2002-03 FA Cup's fifth round.

[32][33] Recorded guest questions come from Nadiya Hussain, Allison Hammond and Dermont O’Leary, Natalie Cassidy, Richard Cadell (with Sooty, Sweep, and Soo), Mr. Blobby, The Vivienne, Stephen Fry, and Ainsley Harriott.