The Biggest Little Game in America is an American college football rivalry featuring the Amherst Mammoths and the Williams Ephs.

The rivalry was started by the actions of Zephaniah Swift Moore, who served as the president of Williams College at the time.

Failing to orchestrate the relocation of Williams College, President Moore opted to embark on the formation of a new educational institution in Amherst, MA.

This series serves as a deliberate nod to the more renowned "Big Three" grouping that traditionally comprises Harvard, Yale, and Princeton.

[5] On November 11, 2017, another memorable chapter was added to the rivalry's annals, as Williams College defeated Amherst in a game held in Williamstown.