The topics for individual articles encompass Dylan's musical forebears, literary influences, personal acquaintances, key career events, musical associates, cultural context, forays into film and writing, and minutiae of all sorts.

[2] Gray's opinions characterize the content found in the Encyclopedia.

Gray summarises the life and work of key early rock and roll performers from the 1950s, as well as entries on influential artists from the fields of country music and the folk music revival.

There are also articles on historical figures, ranging from Robert Browning to Marshall McLuhan.

First editions of the Encyclopedia included a DVD duplicating its content, making it readable on the home computer.