Abbott directed and George Balanchine choreographed the original production, which opened on Broadway at the Alvin Theater on November 23, 1938, after tryouts in New Haven, Connecticut and Boston.

[2] A West End production opened at the Theatre Royal, Drury Lane[3] on November 7, 1963 based on the off-Broadway production, starring Denis Quilley (Antipholus of Ephesus), Maggie Fitzgibbon (Luce), Paula Hendrix (Luciana), Pat Turner (Courtesan), Sonny Farrar (Dromio of Ephesus), Adam Deane (Angelo), John Adams (Sergeant), Edward Atienza (Sorcerer), Ronnie Corbett (Dromio of Syracuse), Lynn Kennington (Adriana) and Bob Monkhouse (Antipholus of Syracuse).

It featured Colm Feore (Antipholus of Ephesus), Geraint Wyn Davies (Antiophlus of Syracuse), Susan Wright (Luce), Goldie Semple (the Courtesan), and Eric McCormack.

[7] A revival directed by Judi Dench was mounted at the Regent's Park Open Air Theatre in London in July through August 1991, and toured the UK in September and October 1991.

The production starred Anastasia Barzee, Helen Carey, Anderson Davis, Ben Davis, Natascia Diaz, Alexander Gemignani, Adam Heller, Benjamin Horen, John Horton, Nehal Joshi, Leslie Kritzer, Michael McGrath, Michael Nansel, Matt Pearson, Tim Rogan, Thomas Adrian Simpson, and Betsy Wolfe.

The cast included Linden Furnell, Taryn Erickson, Mina Kaye, James Simpson, Gimbey Dela Cruz, Elle-May Patterson, Safia Hanifah, Michelle Kraiwitchaicharoen and Oda Maria.

When the pair from Syracuse come to Ephesus, a comedy of errors and mistaken identities ensues when the wives of the Ephesians, Adriana and her servant Luce, mistake the two strangers for their husbands.