[1] The wilderness area comprises 16,337 acres (6,611 ha) administered by the U.S. Forest Service.

The Duckabush River flows through the middle of the area.

The area lies in the rain shadow of the Olympic Mountains, receiving about 80 inches (2,000 mm) of annual precipitation.

Multiple trails can be used to reach The Brothers Wilderness for backpacking, mountain climbing, hunting, hiking, camping, and fishing.

The three-mile Brothers Trail provides access to climbing routes up the double-summit peak of the same name.