Each version of the game features different cartoon characters based on their respective titles: Bugs Bunny, Roger Rabbit, or Mickey Mouse.

The object of the game is to go through a series of rooms collecting items to advance to higher levels while avoiding related cartoon characters.

Some of the levels have boxing gloves, invincibility potions, safes, crates, flower pots, or ten thousand-pound weights that can be used against the enemies in the game.

The North American NES game is a modified version of the Japan-exclusive Family Computer Disk System title, Roger Rabbit.

The NES version of Bugs Bunny Crazy Castle was prominently featured in an Angry Video Game Nerd episode of the same name, which was released on August 5, 2009.