The band opened for the film's costar, comedian Eddie Murphy, during his subsequent Delirious standup comedy tour—during which he referred to them throughout the program—including an hour-long special that aired on HBO.

On January 29, 1983, the BusBoys were also musical guests on an episode of Saturday Night Live with Murphy singing background vocals for the band.

A follow-up song, "Cleanin' Up the Town," written for the soundtrack to the 1984 film Ghostbusters, was a minor hit for the group, reaching #68 on Billboard's Hot 100 Singles chart in the United States.

The BusBoys' first two albums on Arista Records, Minimum Wage Rock & Roll and American Worker, both reached the Billboard 200 chart.

The BusBoys toured extensively with the original line up, appearing with prominent acts such as Linda Ronstadt, Brian Setzer and The Stray Cats, and ZZ Top.

Gus Loundermon (vocals) returned to the band's line-up, along with two new members, Kenny Tomlin (bass) and Jorge Evans (guitar).

In July 2007, the band announced on its website that they were at work on a documentary film, The Story of Brian O'Neal and The BusBoys, directed by Ruth Robinson.