In mid-November 2006, "The Carpal Tunnel of Love" was the first taste of Infinity on High when the band made it available online via AbsolutePunk, before a pre-album release to iTunes on December 12, 2006 as a digital single.

"The Carpal Tunnel of Love" has been referred to as "a prime slab of what the boys have become famous for: highly caffeinated pop-punk mixed with a little white-boy soul and some hard-core yelping.

"[2] The song features Stump singing in a falsetto in the chorus over Trohman's "crunchy" guitars, as well as a breakdown in which Wentz employs unclean vocals,[2] similar to how he used to in his former band, Arma Angelus.

Elements of Wentz's lyrics were alleged to have been stolen from the works of Give Up the Ghost/Some Girls singer and lyricist Wesley Eisold, who sued the band for copyright infringement after the song was released.

On February 2, 2007,[6] the music video was made available on Fall Out Boy's website and was directed by Happy Tree Friends creator Kenn Navarro.