The Case Against Mrs. Ames is a 1936 American mystery drama film written by C. Graham Baker and Gene Towne based on a serial of the same name by Arthur Somers Roche originally published in Collier's Weekly magazine in 1934, and then as a novel in 1936.

[2] The film was directed by William A. Seiter and stars Madeleine Carroll and George Brent, and features Arthur Treacher, Alan Baxter, Beulah Bondi and Alan Mowbray.

Paramount had originally intended to cast Gary Cooper and Carole Lombard in the lead roles.

[3] San Francisco socialite Hope Ames is accused of murdering her husband.

She is prosecuted by District Attorney Matt Logan but is acquitted at her trial.