[4] The first broadcast of the show was on December 4, 2006 with Rulli alongside producer Maureen McMurray, technical director Lou Ruggieri, and phone screener Tom Falcone.

Father Jim Chern also began to appear frequently after his well reception from playing the game "Push-ups for Prayers".

McMurray left later that year to pursue a career with NPR, then later Martha Stewart Living Radio.

In April 2011, Rulli announced that long-time assistant producer/technical director Lou Ruggieri would depart from the show.

Rulli and Grant continued to broadcast each day with frequent appearances by Father Rob Keighron.

It was announced in September 2011 that Keighron would join the show full-time and serve as co-host alongside Rulli, as well as co-producer.

[5] Keighron continued to make periodic in-studio guest appearances with Rulli until June 19, 2014, when he announced his full departure from the show and active ministry.

Following the departure of his co-host Father Rob Keighron in October 2013, Rulli announced a new format for The Catholic Guy.

In the new format, each week Rulli travels around the world to various outreach ministries, colleges, youth organizations, and other Catholic institutions.

Rulli returned to New York to broadcast shows in a similar style to the 2006–2013 format (featuring various segments, games, and occasional guests).