The series features an ensemble cast, including Jharrel Jerome, Asante Blackk, Caleel Harris, Jovan Adepo, Michael K. Williams, Logan Marshall-Green, Joshua Jackson, Blair Underwood, Vera Farmiga, John Leguizamo, Felicity Huffman, Niecy Nash, Aunjanue Ellis, Marsha Stephanie Blake, and Kylie Bunbury.

[5] When They See Us is based on events of the April 19, 1989, Central Park jogger case and explores the lives of the five suspects who were prosecuted on charges related to the sexual assault of a female victim, and of their families.

The five juvenile males of color, the protagonists of the series: Kevin Richardson (Asante Blackk), Antron McCray (Caleel Harris), Yusef Salaam (Ethan Herisse), Korey Wise (Jharrel Jerome), and Raymond Santana (Marquis Rodriguez), were divided by the prosecutor into two groups for trial.

[10] In July 2018, it was announced that Michael K. Williams, Vera Farmiga, John Leguizamo, Felicity Huffman, Jharrel Jerome, and Jovan Adepo had joined the series' main cast.

[12] A week later, it was announced that Chris Chalk, Ethan Herisse, Marquis Rodriguez, Caleel Harris, Freddy Miyares, Justin Cunningham and Asante Blackk had filled out the main cast, both as adults and as teenagers.

The website's critics consensus reads: "Ava DuVernay pulls no punches in When They See Us, laying out the harrowing events endured by the Central Park Five while adding a necessary layer of humanity to their story that challenges viewers to reconsider what it means to find justice in America.

"[20] Daniel Fienberg from The Hollywood Reporter recommended the miniseries in his review by highlighting that "When They See Us is a rigorous attempt to chronicle an epic legal failure and to help restore a sense of the men as individuals, rather than faceless members of a wrongfully accused collective."

He said further, "I watched The Central Park Five earlier this month, and it's a good way to understand the case and its basic facts, but even though [it] has interviews with all five men, it doesn't come close to what DuVernay does here with this cast, her craftsmanship, and Bradford Young's stunning cinematography.

[27] Linda Fairstein, the original New York prosecutor of the case, wrote of the Netflix series in an op-ed for the Wall Street Journal that it was "so full of distortions and falsehoods as to be an outright fabrication."

"[43] John E. Reid & Associates took DuVernay, ARRA, and Netflix to court in October 2019 because the series called the company's once widely used trademark controversial interrogation technique as "universally rejected."

A federal judge dismissed the lawsuit "(b)ecause the First Amendment protects non-factual assertions" and because the plaintiffs did not have sufficient standing to bring the case in the state of Illinois.