According to the 2014 Pew Forum on Religion & Public Life survey, less than 1% of South Carolinans self-identify themselves most closely with the Church of Jesus Christ of Latter-day Saints.

[4] The first LDS member in South Carolina is believed to be Emmanual Masters Murphy, who was baptized in Tennessee in 1836.

When Elder Lysander M. Davis arrived in South Carolina in 1839 (nine years after the Church was organized in New York), he found the Murphys had people prepared for baptism.

Murphy had reportedly spoken with Church President Joseph Smith in the late 1830s, and was told to warn South Carolinians of the destruction soon to hit their state, "the wars that will shortly come to pass, beginning at the rebellion of South Carolina, which will eventually terminate in the death and misery of many souls ... the Southern states will call on other nations, even the nation of Great Britain..." This warning saw reality in 1861, when the Confederates attacked Fort Sumter, and the Civil War commenced.

[5][6][7] The South Carolina Conference was organized on March 31, 1882, with its first president as Elder Willard C. Burton of the Southern States Mission.

Conference headquarters were established at the plantation of John Shaw Black, a man who remained unbaptized to provide refuge for the Church, and a veteran of the Palmetto Sharpshooters.

William (Buck) Canty spoke at the BYU Indian school graduation many times in the 1970s and toured with the Lamanite Generation in 1978.

[13] On November 20–21, 2004, President Hinckley spoke to nearly 12,000 Church members in Columbia, S.C., with proceedings carried to 11 meetinghouses in 11 other stakes in South Carolina and Georgia.

[20] Following Hurricane Katrina in 2005, several thousand Latter-day Saint volunteers from South Carolina and other areas, went to Louisiana and Mississippi.

[22] In 1996, the LDS Church donated 41,000 pounds of food to the Crisis Ministries Center in the Charleston area.

It included the entire state, with wards in Columbia, Greenville, Charleston, Gaffney, Hartsville, Ridgeway, and Spartanburg.