Located in the historic Back Bay of Boston, Massachusetts, at 44 Commonwealth Avenue, the College Club was established by nineteen college educated women whose mission was to form a social club where they and other like-minded women could meet and share companionship.

In December 1890, 76 Marlborough Street, also located in Boston's Back Bay, became the first home of The College Club.

[2] In April 1905, the College Club acquired the clubhouse at 40 Commonwealth Avenue, which contained an Old English drawing room and seven bedrooms, each of which "were furnished and decorated in the colors of various women's colleges: crimson rambler wallpaper for Radcliffe, blue silk curtains for Wellesley, white (with brass beds) for Smith, dawn pink and gray for Vassar."

In 1924, the Club purchased 44 Commonwealth Avenue, which was the family home of Royal E. Robbins, a major stockholder in the Waltham Watch Company.

The brownstone townhouse was built in 1864 and was designed in the High Victorian style.