The show gave TV exposure to nightclub and working men's club comedians of the era, including Russ Abbot, Jim Bowen and Bernard Manning, many of whom went on to enjoy mainstream success in the 1980s.

Working men's clubs were numerous in Britain, especially in the North of England and have been a useful training ground for artists, especially comedians.

The Comedians began as an experiment for Granada TV and was popular during the earlier series, with an LP recording of the show reaching the best-seller charts, and several sell-out national tours following, including a season at the London Palladium.

The comedy frequently took the form of anecdotes or jokes and often involved racist or sexist stereotypes.

Comedians appearing on the show included Russ Abbot (initially as Russ Roberts, later as Russ Abbott), Lennie Bennett, Stan Boardman, Jim Bowen, Jimmy Bright, Duggie Brown, Mike Burton, Dave Butler, Brian Carroll, Frank Carson, Johnnie Casson, Eddie Colinton, Mike Coyne, Colin Crompton, Bob Curtiss, Pauline Daniels, Charlie Daze, Les Dennis, Vince Earl, Steve Faye, Ray Fell, Eddie Flanagan, Stu Francis, Mike Goddard (known as Mike Goodwin in the early years of the show), Ken Goodwin, Jackie Hamilton, Jerry Harris, Jimmy Jones, Mike Kelly, George King, Bobby Knutt, Bernard Manning, Jimmy Marshall, Mike McCabe, Paul Melba, Mick Miller, Pat Mooney, Hal Nolan, Tom O'Connor, Tom Pepper, Bryn Phillips, Al Robbins, Don Reid, Mike Reid, George Roper, Harry Scott, Paul Shane, Pat Tansey, Sammy Thomas, Johnny Wager, Roy Walker, Jos White, Charlie Williams, Lee Wilson and Lenny Windsor.