On their debut album Feast (1983) including a UK top 25 single "Miss the Girl", the band embraced exotica while keeping percussion as the main instrument.

[3] In the late 1990s, they developed a more urban sound on Anima Animus; The Times then described their music as "adventurous art rock built around Siouxsie's extraordinary voice and drummer Budgie's battery of percussion".

Their music was praised by Jeff Buckley,[5] PJ Harvey,[6] Anohni,[7] and name-checked by Neil Hannon of the Divine Comedy.

[9] Melody Maker described Feast as "an album of filtered brilliance, fertile, sensual and erotic",[10] while NME said, "The humours of Sioux's frosty larynx are nakedly outlined against skins of sometimes fabulous quality".

Siouxsie and Budgie went to a stone barn in Jerez, Andalucia, Spain to record Boomerang, an album which blended their music with blues, jazz, flamenco and electronia.

[16] The Creatures then rehearsed with other musicians to play a rearranged version of "Pluto Drive" with Budgie exceptionally on keyboards, for UK TV Show "One Hour with Jonathan Ross".

[20] During February and March 1990, the Creatures toured for the first time in the UK, Europe and the US: they chose to appear as a duo on stage helped with technology and sequencers.

In February 1998, former Velvet Underground member John Cale, then organizing the "With a Little Help from My Friends" festival at the Paradiso in Amsterdam, contacted the Creatures for a collaboration.

The concert, shown on Dutch national television, featured an unreleased Creatures song, "Murdering Mouth", composed for the event and sung in duet with Cale.

[23] In May, Siouxsie and Budgie appeared on British Television show "Later With Jools Holland" with two bass players on their side to perform live two other songs "Disconnected" and "Prettiest Thing" from the forthcoming album.

A stand-alone single, "Sad Cunt", was offered to attendees of two warm-up concerts in London in May prior to the North American tour.

[26] The LA Times reviewed the tour as an "inventive, spirited show", saying: "Cale and the Creatures’ inspired performance struck a perfect balance".

The Times wrote about Anima Animus: "It's entrancing, hypnotic and inventive",[30] and peer PJ Harvey later selected it in her 10 favourite albums released in 1999.

The song "Another Planet" was included on the soundtrack to the film Lost in Space in a version radically reworked by Juno Reactor.

Three one-track CDs – "Murdering Mouth" (live), "Rocket Ship" and "Red Wrapping Paper" – were distributed to fan club members.