Carlota spends much of her time with two hybrids named Cachito and Lupe, as well as the mayordomo Montgomery.

The hacienda's owner, Hernando Izalde, is losing faith that Moreau's research is a good investment.

According to D. Harlan Wilson of the Los Angeles Review of Books, The Daughter of Doctor Moreau re-examines the ideology of H.G.

Wilson writes that "looking backward at Wells becomes increasingly difficult given the white male ethos that utterly dominates his oeuvre".

By the end of the novel, Carlota rejects the view of God as a vengeful deity and adapts a worldview more compatible with panentheism.

[1] Wilson also writes that the theme of patriarchy is most exemplified by the subplot involving Carlota's romance with Eduardo.

After Moreau's death, she is able to "step into her father's role" and kill Eduardo, becoming the hybrids' savior instead of their tormentor.

[3] Library Journal also gave the novel a starred review, calling it "historical science fiction at its best".

"[1] Writing for Paste, Samantha Sullivan praised the complex and dark themes of the novel, including "existential and moral questions that make [Carlota] ponder her faith, the way people frequently “play god” with others, and what exactly family means.

"[5] A review in Book Reporter praised the novel's exploration of themes including "European racism toward the Maya people, ... the horrific work of Dr. Moreau, and the ways in which women are vulnerable to misogyny and violence".

[7] Ian Mond writes that Moreno-Garcia's novel stands on its own "with its evocative prose, post-colonial historical setting that drives the plot, and the introduction of vibrant, fascinating characters,".

[2] The San Francisco Book Review rated the novel four out of five stars, calling it " the perfect modern-day tribute with a feminist spin".

[9] Publishers Weekly also commented on the "wonky pacing", writing that it "occasionally makes it difficult to remain invested in the action".

However, the same review states "the third act rights the ship" and "the ending will linger long in readers’ minds".

Reviewer Archita Mittra called the novel "a chimerical work that arrests the reader’s attention but fails to captivate it", particularly criticizing that the hybrids are used "as props throughout, lacking in emotional complexity".