The series was hosted by emergency room physician and former The Bachelor participant Travis Stork who has appeared frequently on Dr. Phil, with pediatrician Jim Sears,[5] obstetrician/gynecologist Lisa Masterson, and plastic surgeon Andrew Ordon rounding out the discussion panel.

[6] On May 6, 2011, it was announced that Jillian Michaels had been added to the cast of The Doctors doing mainly segments outside the studio, along with serving as a "special correspondent" on Dr.

[1][10] Beginning in 2017, Sako Karakozian, a dentist practicing in Studio City, Los Angeles, has made appearances on the show offering dental advice.

[1] On August 12, 2020, it was announced that the series would undergo several major changes for season 13, including production moving to Stamford, Connecticut, and a revamped format with a new singular host Ian K. Smith, and a theme of "[taking] your power back" amid uncertain times.

The show, whose format was identical to the previous seasons of the English version, features French-Canadian doctors in a similar-looking set with the same color scheme and French wording, though it did not license the theme song and goes without sound effects.

[20][21] In Argentina and Mexico, a Latin American version called Los Doctores is airs on Televisa and Telefe.