[4] The Warehouse was an RSC workshop as much as a showcase and the seasons were remarkably innovative, including Trevor Nunn's acclaimed Stratford 1976 Macbeth, starring Judi Dench and Ian McKellen, which opened at the Covent Garden venue in September 1977 before transferring to the Young Vic.

Among Mendes' productions were John Kander and Fred Ebb's Cabaret, Tennessee Williams's The Glass Menagerie, Stephen Sondheim's Company, Alan Bennett's Habeas Corpus and his farewell duo of Chekhov's Uncle Vanya and Twelfth Night, which transferred to the Brooklyn Academy of Music.

Many well-known actors have appeared at the theatre, including Nicole Kidman (The Blue Room), Gwyneth Paltrow (Proof), Ian McKellen (The Cut) and Ewan McGregor (Othello).

It commenced on 12 September 2008, with Kenneth Branagh in the title role of Chekhov's Ivanov, given in a new version by Tom Stoppard and directed by Grandage.

[7] The West End season continued with Derek Jacobi in Twelfth Night, Judi Dench in Yukio Mishima's Madame de Sade and Jude Law in Hamlet, all directed by Grandage.

[10] In February 2011, the Donmar collaborated with the National Theatre Live programme to broadcast its production of King Lear, starring Derek Jacobi, to cinemas around the world.

Her first season also included Robert Holman's 1987 play, Making Noise Quietly, directed by Peter Gill; Jack Thorne's new version of The Physicists by Swiss playwright Friedrich Duerrenmatt; Brian Friel's Philadelphia, Here I Come!, directed by Lyndsey Turner; and Rourke's own production of Jean Racine's Berenice, in a new translation by Alan Hollinghurst and Phyllida Lloyd's all female Julius Caesar, which later went on to play at the St. Ann's Warehouse, New York.

This theatre housed the all-female Shakespeare trilogy: The Tempest, Julius Caesar and Henry IV, directed by Phyllida Lloyd, from September to December 2016.

Further planned productions include [Blank] by Alice Birch, the UK premiere of Mike Lew's Teenage Dick and the season closes with Caryl Churchill's Far Away.

The theatre reopened in September 2021 and further productions included Henry V with Kit Harington, Macbeth with David Tennant and Cush Jumbo, and the musicals The Band's Visit and Next to Normal.