[2] The series features the Duke boys and their cousin Daisy in an automobile race around the world against Boss Hogg, Sheriff Rosco P. Coltrane, and Rosco's dog Flash in a duel for the prize money which the Dukes hope to use to keep the family farm from being foreclosed by Boss Hogg.

The first season took place during the period of the live-action series' temporary replacement of the original actors with similar characters, Coy and Vance Duke, after Tom Wopat and John Schneider walked out over a dispute about royalties from related merchandise.

The series followed no particular logical geographic path; for instance, consecutive episodes feature appearances in Venice, Morocco, the Arctic Ocean, London, Greece, India, Uzbekistan, Hong Kong and Scotland.

Starting in the very first episode of this season, Tom Wopat and John Schneider return as Luke and Bo in the regular Dukes of Hazzard series, and take over for Coy and Vance in the cartoon.

On December 7, 2010, Warner Archive released The Dukes: The Complete Series on DVD in region 1 as part of their Hanna-Barbera Classic Collection.